Manju Bhat
Position: Dean Department: College of Arts, Sciences, Business and Education (CASBE)
Contact Info
Office: Carolina Hall, Suite 130 Phone: 336-750-2214 Email: bhatmb@wssu.edu
Biography
Manju Bhat (Ph.D., Case Western Reserve University) is Dean of the College of Arts, Sciences, Business and Education. He also serves as the Hanes Distinguished Professor of the Humanities and Associate Professor of Physiology in the Department of Biological Sciences. Formerly, Dr. Bhat served as Chair of the Department of Biological Sciences. A native of India, Dr. Bhat obtained his undergraduate degree in Veterinary medicine (Karnataka Veterinary College, India) and master’s in pharmacology degrees from Indian Veterinary Research Institute and University of Alberta. His doctoral research work in Physiology focused on investigating the structure-function relationship of calcium release channels and skeletal muscle physiology. Prior to joining WSSU in 2008, Dr. Bhat was a research faculty at Cleveland Clinic where he conducted research on the pathophysiology of pain mechanisms. His primary research interest is to investigate the role of calcium and calcium channels in sensory physiology and anesthetic-mediated regulation of pain signaling pathways. Dr. Bhat is also interested in teaching and learning technologies, STEM education, and the value of data analytics tools (e.g., EAB Navigate) to improve student retention and success. He teaches undergraduate courses in Anatomy & Physiology.
Educational Background
- PhD, 1997, Case Western Reserve University, Cleveland, OH U.S.A.
- MSc, 1993, University of Alberta, Edmonton, Canada
- MVSc, 1989, Indian Veterinary Research Institute, Izzatnagar, India
- BVSc, 1986, University of Agricultural Sciences, Bangalore, India
Research and Project Interests
- Mechanisms of Calcium Signaling in Sensory Neurons Anesthetic-mediated Regulation of Calcium Signaling
Manjunatha B. Bhat, Santosh K. Mishra, and Vellanki Raviprakash (1989). Differential susceptibility of cholinergic and non-cholinergic neurogenic responses to calcium channel blockers and low Ca2+ medium in rat urinary bladder. Br. J. Pharmacol. 96: 837-842.
Manjunatha B. Bhat, Santosh K. Mishra, and Vellanki Raviprakash (1989). Sources of calcium for ATP-induced contractions in rat urinary bladder smooth muscle. Eur. J. Pharmacol. 164: 163-166.
Jianjie Ma, Manjunatha B. Bhat, and Jiying Zhao. (1995). Rectification of skeletal ryanodine receptor mediated by FK506 binding protein. Biophys. J. 69: 2398-2404.
Manjunatha B. Bhat, Jiying Zhao, Hiroshi Takeshima, and Jianjie Ma. (1997). Functional calcium release channel formed by the carboxyl-terminal portion of ryanodine receptor. Biophys. J. 73: 1329-1336.
Manjunatha B. Bhat, Jiying Zhao, Salim Hayek, Eric C. Freeman, Hiroshi Takeshima, and Jianjie Ma. (1997). Deletion of a.a. 1641-2437 from the foot region of skeletal muscle ryanodine receptor alters conduction properties of the calcium release channel. Biophys. J. 73: 1320-1328.
Manjunatha B. Bhat, Jiying Zhao, Weijin Zang, C. William Balke, Hiroshi Takeshima, W. Gil Wier, and Jianjie Ma. (1997). Caffeine-induced release of intracellular calcium from Chinese hamster ovary cells expressing skeletal muscle ryanodine receptor: Effects on full-length and carboxyl-terminal portion of calcium release channel. J. Gen. Physiol. 101: 749-762.
Minh Lam, Manjunatha B. Bhat, Gabriel Nunez, Jianjie Ma, and Clark W. Distelhorst. (1998). Regulation of Bcl-xL channel activity by calcium. J. Biol. Chem. 273: 17307-17310.
Kaisa M. Heiskanen, Manjunatha B. Bhat, Jianjie Ma, and Anna-Liisa Nieminen. (1999). Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells. J. Biol. Chem. 274: 5674-5678.
Manjunatha B. Bhat, Salim M. Hayek, Jiying Zhao, Weijin Zang, Hiroshi Takeshima, Gil Wier, and Jianjie Ma. (1999). Expression and functional characterization of the cardiac muscle ryanodine receptor calcium release channel in CHO cells. Biophys. J. 77: 808-816.
Salim M. Hayek, Jiying Zhao, Manjunatha B. Bhat, Xuehong Xu, Ramakrishnan Nagaraj, Zui Pan, Hiroshi Takeshima, and Jianjie Ma. (1999). A negatively charged region of the skeletal muscle ryanodine receptor is involved in Ca-dependent regulation of the Ca release channel. FEBS Lett. 461: 157-164.
Xuehong Xu, Manjunatha B. Bhat, Miyuki Nishi, Hisoshi Takeshima, and Jianjie Ma (2000). Molecular cloning of cDNA encoding the Drosophila ryanodine receptor and functional studies of the carboxyl-terminal calcium release channel. Biophys. J. 78: 1270-1281.
Zui Pan, Derek Damron, Anna-Liisa Nieminan, Manjunatha B. Bhat, and Jianjie Ma. (2000). Depletion of intracellular Ca2+ by caffeine and ryanodine induces apoptosis of Chinese hamster ovary cells transfected with ryanodine receptor. J. Biol. Chem. 275: 19978-19984.
Salim M. Hayek, Xinsheng Zhu, Manjunatha B. Bhat, Jiying Zhao, Hiroshi Takeshima, Hector H. Valdivia, and Jianjie Ma. (2000). Characterization of a calcium regulation domain of the skeletal muscle ryanodine receptor. Biochem. J. 351: 57‑65.
Jerry E. Chipuk, Manjunatha B. Bhat, Andrew Y. Hsing, Jianjie Ma, and David Danielpour (2001). Bcl-xL blocks TGF-b1-induced apoptosis by inhibiting cytochrome C release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells. J. Biol. Chem. 276: 26614-26621.
Zui Pan*, Manjunatha B. Bhat*, Dongwook Shin, Anna-Liisa Nieminen, and Jianjie Ma. (2001). Synergistic movements of Ca2+ and Bax in cells undergoing apoptosis. J. Biol. Chem. 276: 32257-32263. *equal contribution
Manjunatha B. Bhat, and Jianjie Ma. (2002). The transmembrane segment of ryanodine receptor contain an intracellular membrane retention signal for Ca2+ release channel. J. Biol. Chem. 277: 8597-8601.
Kalanithee Paul-Pletzer, Takeshi Yamamoto, Manjunatha B. Bhat, Jianjie Ma, Noriaki Ikemoto, Leslie S. Jimenez, Hiromi Morimoto, Philip G. Williams, and Jerome Parness. (2002). Partial mapping of the dantrolene-binding site on the skeletal muscle ryanodine receptor. J. Biol. Chem. 277: 34918-34923.
Dong Wook Shin , Zui Pan, Eun Kyung Kim, Jae Man Lee, Manjunatha B. Bhat, Jerome Parness, Do Han Kim, and Jianjie Ma. (2003). A retrograde signal from calsequestrin for the regulation of store-operated Ca2+ entry in skeletal muscle. J. Biol. Chem. 278: 3286-3292.
Mary L. Ruehr, Mary A. Russell, Donald G. Ferguson, Manjunatha B. Bhat, Jianjie Ma, Derek S. Damron, John D. Scott, and Meredith Bond. (2003). Targeting of PKA by mAKAP regulates phosphorylation and function of the skeletal muscle ryanodine receptor. J. Biol. Chem. 278: 24831-24836.
Sravan Mandadi, Mistuko Numazaki, Makoto Tominaga, Manjunatha B. Bhat, Patricia J. Armati, and Basil D. Roufogalis. (2004). Activation of protein kinase C reverses capsaicin-induced calcium dependent desensitization of TRPV1 ion channels. Cell Calcium. 35: 471-478.
Zui Pan, Yutaka Hirata, Ramakrishnan Y. Nagaraj, Jiying Zhao, Miyuki Nishi, Salim M. Hayek, Manjunatha B. Bhat, Hiroshi Takeshima, and Jianjie Ma. (2004). Co-expression of mg29 and ryanodine receptor leads to apoptotic cell death-effect mediated by intracellular Ca2+ release. J. Biol. Chem. 279: 19387-19390.
BingFen Liu, Manjunatha B. Bhat, Dawn G. Smith, and Ram H. Nagaraj. (2004). Effect of dicarbonyl modification of fibronectin on retinal capillary pericytes. Invest. Ophthalmol. Vis. Sci. 45: 1983-1995.
BingFen Liu, Manjunatha B. Bhat, and Ram H. Nagaraj. (2004). Alpha-B-crystallin inhibits glucose-induced apoptosis in vascular endothelial cells. Biochem. Biophys. Res. Comm. 321: 254-258.
Ram H. Nagaraj, Tomoko Oya-Ito, Manjunatha B. Bhat, and Bingfen Liu. (2005). Dicarbonyl stress and apoptosis of vascular cells: prevention by alpha-B-crystallin. Ann. N.Y. Acad. Sci. 1043: 158-165.
Ashis Biswas, Antonia Miller, Tomoko Oya-Ito, Puttur Santhoshkumar, Manjunatha B. Bhat, and Ram H. Nagaraj. (2006). Effect of site-directed mutagenesis of methylglyoxal modifiable arginine residues on the structure and chaperone function of human aA-crystallin. Biochem. 45: 4569-4577.
Antonia G. Miller, Dawn G. Smith, Manjunatha B. Bhat, and Ram H. Nagaraj. (2006). Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions. J. Biol. Chem. 281: 11864-11871.
Sanjoy K. Bhattacharya, Manjunatha B. Bhat, and Hidenari Takahara. (2007). Calcium modulation of peptidyl arginine deaminase 2 and implication for neurodegeneration. Exp. Eye. Res. 31: 1063-1071.
Ashis Biswas, Jeffery Goshe, Antonia G. Miller, Puttur Santhoshkumar, Manjunatha B. Bhat, and Ram H. Nagaraj. (2007).Paradoxical Effects of Substitution and Deletion Mutation of Arg56 on the Structure and Chaperone Function of Human aB-crystallin. Biochem. 46: 1117-1127.
ChangWoo Lee, Si Ae Hwang, Sei-Heon Jang, Manjunatha B. Bhat, and Sadashiva S. Karnik. (2007). Manifold active-state conformations in GPCRs: Agonist-activated constitutively active mutant AT1 receptor preferentially couples to Gq compared to the wild-type AT1 receptor. FEBS Lett. 581: 2517-2522.
Richard Stewart, Lele Song, Simon M. Carter, Charalambos Sigalas, Nathan R. Zaccai, Venkateswarlu Kanamarlapudi, Manjunatha B. Bhat, Hiroshi Takeshima and Rebecca Sitsapesan. (2008). Single-channel characterization of the rabbit recombinant RyR2 reveals a novel inactivation property of physiological concentrations of ATP. J. Membrane Biol. 222: 65-77.
Pinaki Chaudhuri, Scott M. Colles, Manjunatha B. Bhat, and Linda M. Graham. (2008). Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement. Mol Biol Cell. 19:3203-3211
Ram H. Nagaraj, Ashis Biswas, Antonia G. Miller, Tomoko Oya-Ito, and Manjunatha B. Bhat (2008). The other side of the Maillard reaction. Ann. N.Y. Acad. Sci. 1126: 107-112.
Qing Liu, Manjunatha B. Bhat, Wayne D. Bowen, and Jianguo Cheng. (2009). Signaling pathways from CB1 receptor activation to inhibition of NMDA-mediated calcium influx and neurotoxicity in dorsal root ganglion neurons. J. Pharmacol Exp. Ther. 331: 1062-1070.
Hamiyet Unal, Rajaganapathy Jagannathan, Manjunatha B. Bhat, and Sadashiva S. Karnik. (2010). Ligand-specific conformation of extracellular loop-2 in the Angiotensin I type 2 receptor. J. Biol. Chem. 285: 16341-16350.
Manjunatha B. Bhat. (2013). Cultivating problem solving and decision-making abilities – the teacher’s role. In: Facilitating seven ways of learning (Davis J.R., Arend B.D., Eds.) Stylus, Steerling, VA. Pp 168-169 (case study).
Taylor Young, Brianna Hughes, Manjunatha B. Bhat, and Jeffrey L. Overholt. (2014). Pain sensing mechanisms: Effects of propofol and capsaicin on TRP currents in DRG cells. Annual Biomedical Research Conference for Minority Students (ABRCMS), San Antonio, TX, Nov 12-15, 2014.
Tanya Zubov, Bianca Golden, Manjunatha B. Bhat. (2016). Mechanisms of propofol-induced pain: effects of capsaicin- and ryanodine receptors. Annual Biomedical Research Conference for Minority Students (ABRCMS), Tampa, FL. Nov 8-13, 2016.
Human Anatomy & Physiology Society (HAPS)